Studies on the anticoagulant phenylindanedione. I. The effect of emulsified vitamin K1 on phenylindanedione-induced hypoprothrombinemia.
نویسندگان
چکیده
Induced Hypoprothrombinemia By CHARLES G. GUTTAS, M.D., WILLIAM C. MOLONEY, M.D. AND HERBERT S. SI5E, M.D. P HENYLINDANEDIONE, a drung des-eloped! by certain Fretsch ss’orkers because of a more tratssitory prothromhopeisic actiots than dicoumarol,’ has been used extetssively as an anticoagutlatst for the past eighteeis months atthe Bostots City Hospital.3 While phenylitsdatsedione is knosvts to be ati effective drug ins the productiots of hypoprot-hrombitsemia,4 ats object-ion to its clitsical use has beers the cotseept that the hypoprothrombinemic state is tsot coutisteracted by vitamin K active compounds.2 6
منابع مشابه
Efficacy of water-soluble derivatives of vitamin K1 in counteracting drug-induced hypoprothrombinemia.
By CHARLES W. MUSHErF, KANE L. KELLEY AND RALPH HLRSCHMANN H YPOPROTHROMBINEMIA, resulting from simple vitamin K lack such as occurs in dietary deficiency in the chick or in absorptive difficulties in man, responds almost equally well to treatment with vitamin K1 (2-methyl3-phytyl-1,4-naphthoquinone) or Menadione (2-methyl-1,4-naphthoquinone) and water-soluble Menadione analogues.13 That this m...
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Since the discovery (Soulier and Gueguen, 1947) that phenylindanedione (P.I.D.) was an anticoagulant which effectively altered the one-stage prothrombin time it has been used extensively in the treatment of cases of thrombosis (Blaustein, 1950; Blaustein, Shnayerson, and Wallach, 1953; Dennis, Coon, Hodgson, and Duff, 1952; Toohey, 1953). Clinically it appears to produce the same effect as dico...
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PHENYLINDANEDIONE is one of several oral anticoagulants in wide use at the present time. It is generally considered to be non-toxic, but adverse reactions to the drug have been reported. We have been able to find six instances of agranulocytosis, two of jaundice,' and six of rash without fever 13 in the world literature. One of the instances of agranulocytosis was fatal. The purpose of this com...
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ANTICOAGULANTS have been used clinically for the past 25 years, starting with the initial work of Murray anld Best,' and their use has inereased steadilv and continuously each year since that time. Fairly early. however, there were reports of spontaneous hemorrhage from the use of anticoagulants. With the introduction and widespread use of the indirect anticoagulants reports of hemorrhage incre...
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ورودعنوان ژورنال:
- Blood
دوره 8 3 شماره
صفحات -
تاریخ انتشار 1953